Hepatic Labeling & Angiography

Hepatic Labeling & Angiography 2017-11-14T15:38:28+00:00

Hepatic labeling by MultiLys 780 T2 PEG observed by fluorescent microscope 2 weeks after intravenous injection

Photo Julien Santelli U-INSERM 1043

MultiLys 780 T2 is a multimodal probe, which can be used to perform angiography. Indeed, its contrasting properties with X-rays, MRI and fluorescence allow to visualize blood vessels when injected directly into the bloodstream. Coated with polyethylene glycol layer, it has a long half life in blood circulation (≈ 40 min in mice)

However, after 1 h or more, this probe is picked up by the reticuloendothelial system and is stored in the liver for several weeks. Therefore, it may also serve as a liver marker. The healthy tissues of the liver will be labeled, unlike cancerous or non-functional tissues.

Hepatic labeling by MultiLys 780 TPEG observed by MRI over time

Photos: Eddy Magdeleine, société ICELLTIS
* For instance you can disperse 3mg of particles in 1ml of glucose water to prepare 5 x 200 ml of injectable solution
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